Research Articles

 

IQGAP1 regulates ERK1/2 and AKT signaling in the heart and sustains functional remodeling upon pressure overload.

Sbroggiò M, Carnevale D, Bertero A, Cifelli G, De Blasio E, Mascio G, Hirsch E, Bahou WF, Turco E, Silengo L, Brancaccio M, Lembo G, Tarone G.

Cardiovasc Res. 2011 Apr 14. [Epub ahead of print]

Integrating Cardiac PIP(3) and cAMP Signaling through a PKA Anchoring Function of p110γ.

Perino A, Ghigo A, Ferrero E, Morello F, Santulli G, Baillie GS, Damilano F, Dunlop AJ, Pawson C, Walser R, Levi R, Altruda F, Silengo L, Langeberg LK, Neubauer G, Heymans S, Lembo G, Wymann MP, Wetzker R, Houslay MD, Iaccarino G, Scott JD, Hirsch E.

Mol Cell. 2011 Apr 8;42(1):84-95.

Chronic Type A aortic dissection: could surgical intervention be guided by molecular markers?

Carnevale D, Lembo G, Frati G.

J Cell Mol Med. 2011 Mar 24. doi: 10.1111/j.1582-4934.2011.01314.x. [Epub ahead of print]

Distinct effects of leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure.

Damilano F, Franco I, Perrino C, Schaefer K, Azzolino O, Carnevale D, Cifelli G, Carullo P, Ragona R, Ghigo A, Perino A, Lembo G, Hirsch E.

Circulation. 2011 Feb 1;123(4):391-9. Epub 2011 Jan 17.

Role of neuroinflammation in hypertension-induced brain amyloid pathology.

Carnevale D, Mascio G, Ajmone-Cat MA, D'Andrea I, Cifelli G, Madonna M, Cocozza G, Frati A, Carullo P, Carnevale L, Alleva E, Branchi I, Lembo G, Minghetti L.

Neurobiol Aging. 2010 Oct 18. [Epub ahead of print] 

Protein kinase Cθ is required for cardiomyocyte survival and cardiac remodeling.

Paoletti R, Maffei A, Madaro L, Notte A, Stanganello E, Cifelli G, Carullo P, Molinaro M, Lembo G, Bouché M.

Cell Death Dis. 2010 May 27;1(5):e45. 

Melusin gene (ITGB1BP2) nucleotide variations study in hypertensive and cardiopathic patients.

Palumbo V, Segat L, Padovan L, Amoroso A, Trimarco B, Izzo R, Lembo G, Regitz-Zagrosek V, Knoll R, Brancaccio M, Tarone G, Crovella S.

BMC Med Genet. 2009 Dec 17;10:140.

Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial.

Konstam MA, Neaton JD, Dickstein K, Drexler H, Komajda M, Martinez FA, Riegger GA, Malbecq W, Smith RD, Guptha S, Poole-Wilson PA; HEAAL Investigators.

Lancet. 2009 Nov 28;374(9704):1840-8. Epub 2009 Nov 16. Erratum in: Lancet. 2009 Dec 5;374(9705):1888. 

Pressure-induced vascular oxidative stress is mediated through activation of integrin-linked kinase 1/betaPIX/Rac-1 pathway.

Vecchione C, Carnevale D, Di Pardo A, Gentile MT, Damato A, Cocozza G, Antenucci G, Mascio G, Bettarini U, Landolfi A, Iorio L, Maffei A, Lembo G.

Hypertension. 2009 Nov;54(5):1028-34. Epub 2009 Sep 21. 

Usual versus tight control of systolic blood pressure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised trial.

Verdecchia P, Staessen JA, Angeli F, de Simone G, Achilli A, Ganau A, Mureddu G, Pede S, Maggioni AP, Lucci D, Reboldi G; Cardio-Sis investigators.

Lancet. 2009 Aug 15;374(9689):525-33. Erratum in: Lancet. 2009 Sep 12;374(9693):880. 

Tumor necrosis factor-alpha mediates hemolysis-induced vasoconstriction and the cerebral vasospasm evoked by subarachnoid hemorrhage.

Vecchione C, Frati A, Di Pardo A, Cifelli G, Carnevale D, Gentile MT, Carangi R, Landolfi A, Carullo P, Bettarini U, Antenucci G, Mascio G, Busceti CL, Notte A, Maffei A, Cantore GP, Lembo G.

Hypertension. 2009 Jul;54(1):150-6. Epub 2009 May 26. 

Rationale and design of a randomized, double-blind, parallel-group study of terutroban 30 mg/day versus aspirin 100 mg/day in stroke patients: the prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) study.

Bousser MG, Amarenco P, Chamorro A, Fisher M, Ford I, Fox K, Hennerici MG, Mattle HP, Rothwell PM; PERFORM Study Investigators.

Cerebrovasc Dis. 2009;27(5):509-18. Epub 2009 Apr 16.

Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study.

Diener HC, Sacco RL, Yusuf S, Cotton D, Ounpuu S, Lawton WA, Palesch Y, Martin RH, Albers GW, Bath P, Bornstein N, Chan BP, Chen ST, Cunha L, Dahlöf B, De Keyser J, Donnan GA, Estol C, Gorelick P, Gu V, Hermansson K, Hilbrich L, Kaste M, Lu C, Machnig T, Pais P, Roberts R, Skvortsova V, Teal P, Toni D, VanderMaelen C, Voigt T, Weber M, Yoon BW; Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) study group.

Lancet Neurol. 2008 Oct;7(10):875-84. Epub 2008 Aug 29. Erratum in: Lancet Neurol. 2008 Nov;7(11):985. 

Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: a randomised controlled trial.

Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease (TRANSCEND) Investigators, Yusuf S, Teo K, Anderson C, Pogue J, Dyal L, Copland I, Schumacher H, Dagenais G, Sleight P.

Lancet. 2008 Sep 27;372(9644):1174-83. Epub 2008 Aug 29. Erratum in: Lancet. 2008 Oct 18;372(9647):1384. 

Telmisartan to prevent recurrent stroke and cardiovascular events.

Yusuf S, Diener HC, Sacco RL, Cotton D, Ounpuu S, Lawton WA, Palesch Y, Martin RH, Albers GW, Bath P, Bornstein N, Chan BP, Chen ST, Cunha L, Dahlöf B, De Keyser J, Donnan GA, Estol C, Gorelick P, Gu V, Hermansson K, Hilbrich L, Kaste M, Lu C, Machnig T, Pais P, Roberts R, Skvortsova V, Teal P, Toni D, VanderMaelen C, Voigt T, Weber M, Yoon BW; PRoFESS Study Group.

N Engl J Med. 2008 Sep 18;359(12):1225-37. Epub 2008 Aug 27.

Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke.

Sacco RL, Diener HC, Yusuf S, Cotton D, Ounpuu S, Lawton WA, Palesch Y, Martin RH, Albers GW, Bath P, Bornstein N, Chan BP, Chen ST, Cunha L, Dahlöf B, De Keyser J, Donnan GA, Estol C, Gorelick P, Gu V, Hermansson K, Hilbrich L, Kaste M, Lu C, Machnig T, Pais P, Roberts R, Skvortsova V, Teal P, Toni D, Vandermaelen C, Voigt T, Weber M, Yoon BW; PRoFESS Study Group.

N Engl J Med. 2008 Sep 18;359(12):1238-51. Epub 2008 Aug 27. 

Telmisartan, ramipril, or both in patients at high risk for vascular events.

ONTARGET Investigators, Yusuf S, Teo KK, Pogue J, Dyal L, Copland I, Schumacher H, Dagenais G, Sleight P, Anderson C.

N Engl J Med. 2008 Apr 10;358(15):1547-59. Epub 2008 Mar 31. 

Efficacy of manidipine/delapril versus losartan/hydrochlorothiazide fixed combinations in patients with hypertension and diabetes.

Roca-Cusachs A, Schmieder RE, Triposkiadis F, Wenzel RR, Laurent S, Kohlmann O Jr, Fogari R; MORE Study Group.

J Hypertens. 2008 Apr;26(4):813-8. 

Myocardial Pitx2 differentially regulates the left atrial identity and ventricular asymmetric remodeling programs.

Tessari A, Pietrobon M, Notte A, Cifelli G, Gage PJ, Schneider MD, Lembo G, Campione M.

Circ Res. 2008 Apr 11;102(7):813-22. Epub 2008 Feb 21. 

Efficacy of aliskiren/hydrochlorothiazide single-pill combinations in aliskiren non-responders.

Nickenig G, Simanenkov V, Lembo G, Rodriguez P, Salko T, Ritter S, Zhang J.

Blood Press. 2008;17 Suppl 2:31-40. 

Resistin impairs insulin-evoked vasodilation.

Gentile MT, Vecchione C, Marino G, Aretini A, Di Pardo A, Antenucci G, Maffei A, Cifelli G, Iorio L, Landolfi A, Frati G, Lembo G.

Diabetes. 2008 Mar;57(3):577-83. Epub 2007 Dec 7. Erratum in: Diabetes. 2010 Jan;59(1):319. Dosage error in article text. 

Randomized study of traditional versus aggressive systolic blood pressure control (Cardio-Sis): rationale, design and characteristics of the study population.

Cardio-Sis Study Group.

J Hum Hypertens. 2008 Apr;22(4):243-51. Epub 2007 Nov 29. 

Antihypertensive efficacy and safety of manidipine versus amlodipine in elderly subjects with isolated systolic hypertension: MAISH study.

Payeras AC, Sladek K, Lembo G, Alberici M.

Clin Drug Investig. 2007;27(9):623-32. 

Beta-amyloid deposition in brain is enhanced in mouse models of arterial hypertension.

Gentile MT, Poulet R, Di Pardo A, Cifelli G, Maffei A, Vecchione C, Passarelli F, Landolfi A, Carullo P, Lembo G.

Neurobiol Aging. 2009 Feb;30(2):222-8. Epub 2007 Jul 27.

Nebivolol induces nitric oxide release in the heart through inducible nitric oxide synthase activation.

Maffei A, Di Pardo A, Carangi R, Carullo P, Poulet R, Gentile MT, Vecchione C, Lembo G.

Hypertension. 2007 Oct;50(4):652-6. Epub 2007 Jul 30.

A novel mechanism of action for statins against diabetes-induced oxidative stress.

Vecchione C, Gentile MT, Aretini A, Marino G, Poulet R, Maffei A, Passarelli F, Landolfi A, Vasta A, Lembo G.

Diabetologia. 2007 Apr;50(4):874-80. Epub 2007 Feb 6.

Assessment of the antihypertensive efficacy of various doses of delapril by office and ambulatory blood pressure measurement: the DEFIND study.

Otero ML, Parisi G, Maffei A, Vecchione C, Lembo G; DEFIND Study Group.

Adv Ther. 2006 May-Jun;23(3):421-32.

Characterization of nitric oxide release by nebivolol and its metabolites.

Maffei A, Vecchione C, Aretini A, Poulet R, Bettarini U, Gentile MT, Cifelli G, Lembo G.

Am J Hypertens. 2006 Jun;19(6):579-86.

Emilin1 links TGF-beta maturation to blood pressure homeostasis.

Zacchigna L, Vecchione C, Notte A, Cordenonsi M, Dupont S, Maretto S, Cifelli G, Ferrari A, Maffei A, Fabbro C, Braghetta P, Marino G, Selvetella G, Aretini A, Colonnese C, Bettarini U, Russo G, Soligo S, Adorno M, Bonaldo P, Volpin D, Piccolo S, Lembo G, Bressan GM.

Cell. 2006 Mar 10;124(5):929-42.

Selective Rac-1 inhibition protects from diabetes-induced vascular injury.

Vecchione C, Aretini A, Marino G, Bettarini U, Poulet R, Maffei A, Sbroggiò M, Pastore L, Gentile MT, Notte A, Iorio L, Hirsch E, Tarone G, Lembo G.

Circ Res. 2006 Feb 3;98(2):218-25. Epub 2005 Dec 15.

Acute hypertension induces oxidative stress in brain tissues.

Poulet R, Gentile MT, Vecchione C, Distaso M, Aretini A, Fratta L, Russo G, Echart C, Maffei A, De Simoni MG, Lembo G.

J Cereb Blood Flow Metab. 2006 Feb;26(2):253-62.

Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice.

Potenza N, Vecchione C, Notte A, De Rienzo A, Rosica A, Bauer L, Affuso A, De Felice M, Russo T, Poulet R, Cifelli G, De Vita G, Lembo G, Di Lauro R.

EMBO Rep. 2005 May;6(5):432-7.

Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload.

De Acetis M, Notte A, Accornero F, Selvetella G, Brancaccio M, Vecchione C, Sbroggiò M, Collino F, Pacchioni B, Lanfranchi G, Aretini A, Ferretti R, Maffei A, Altruda F, Silengo L, Tarone G, Lembo G.

Circ Res. 2005 May 27;96(10):1087-94. Epub 2005 Apr 28. Erratum in: Circ Res. 2005 Jul 8;97(1):e5.

Angiotensin II type 2 receptors contribute to vascular responses in spontaneously hypertensive rats treated with angiotensin II type 1 receptor antagonists.

Cosentino F, Savoia C, De Paolis P, Francia P, Russo A, Maffei A, Venturelli V, Schiavoni M, Lembo G, Volpe M.

Am J Hypertens. 2005 Apr;18(4 Pt 1):493-9.

Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma.

Vecchione C, Patrucco E, Marino G, Barberis L, Poulet R, Aretini A, Maffei A, Gentile MT, Storto M, Azzolino O, Brancaccio M, Colussi GL, Bettarini U, Altruda F, Silengo L, Tarone G, Wymann MP, Hirsch E, Lembo G.

J Exp Med. 2005 Apr 18;201(8):1217-28. Epub 2005 Apr 11.

Mechanisms of soluble beta-amyloid impairment of endothelial function.

Gentile MT, Vecchione C, Maffei A, Aretini A, Marino G, Poulet R, Capobianco L, Selvetella G, Lembo G.

J Biol Chem. 2004 Nov 12;279(46):48135-42. Epub 2004 Aug 19.

PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects.

Patrucco E, Notte A, Barberis L, Selvetella G, Maffei A, Brancaccio M, Marengo S, Russo G, Azzolino O, Rybalkin SD, Silengo L, Altruda F, Wetzker R, Wymann MP, Lembo G, Hirsch E.

Cell. 2004 Aug 6;118(3):375-87.

Polymorphisms in human endothelin-converting enzyme (ECE-1) promoter can modulate ECE-1 gene expression.

Gentile MT, Lembo G.

J Hypertens. 2003 Nov;21(11):2013-4. No abstract available. 

Alpha-1B adrenergic receptor knockout mice are protected against methamphetamine toxicity.

Battaglia G, Fornai F, Busceti CL, Lembo G, Nicoletti F, De Blasi A.

J Neurochem. 2003 Jul;86(2):413-21.

Cooperation between insulin and leptin in the modulation of vascular tone.

Vecchione C, Aretini A, Maffei A, Marino G, Selvetella G, Poulet R, Trimarco V, Frati G, Lembo G.

Hypertension. 2003 Aug;42(2):166-70. Epub 2003 Jun 30.

Left ventricular hypertrophy is associated with asymptomatic cerebral damage in hypertensive patients.

Selvetella G, Notte A, Maffei A, Calistri V, Scamardella V, Frati G, Trimarco B, Colonnese C, Lembo G.

Stroke. 2003 Jul;34(7):1766-70. Epub 2003 Jun 12.

 

Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload.

Brancaccio M, Fratta L, Notte A, Hirsch E, Poulet R, Guazzone S, De Acetis M, Vecchione C, Marino G, Altruda F, Silengo L, Tarone G, Lembo G.

Nat Med. 2003 Jan;9(1):68-75. Epub 2002 Dec 23.